We are a multidisciplinary research laboratory composed of engineers, biologists and physicians working in the area of SYSTEMS BIOLOGY and BIOENGINEERING. We apply novel biological and engineering appoaches for modeling biological systems, proteomic profiling, and assay automation with applications in drug development and medical devices.

--------------------------------------------------------------------------------------------------------------------------

Areas or Research:

1. Modeling Biological Systems: We combine computational techniques with high-throughput experimental data to model the behavior of cellular systems. We apply novel computational techniques to (i) construct models of cell behavior via construction of signaling pathways in normal and diseased states, (ii) predict drug effects (iii) identify in-silico new targets for optimizing therapeutic interventions

2. Medical Devices: We design and build custom devices. Two are the main areas of research: (i) A devices that is utilised in automating protein measurements and help us improving the quality, sensitivity, and throughput of our proteomic platforms (ii) A device for real-time monitoring the mechanical properties of cartilage and tissue-engineering constructs. This device can be used for screening the effects of proteins in cartilage explants and the screening of compounds.

3. Biomechanics: We employ biomechanics for monitoring tissue mechanical properties in-vitro and real time. Our focus is particulartly on cartilage degeneration using a combination of systems biology and biomechanical approaches.