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Leonidas G Alexopoulos, PhD
Dept. of Mechanical Engineering, National Technical University of Athens
Heroon Polytechniou 9, 15780 Zografou, Athens, GREEC

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As of Sept 1st 2011: 25 papers, 510 citations (excl. self citations), h-index:14 (Sourse: Scopus)

You can also visit my home page at GOOGLE SCHOLAR for an up-to-date list of all publications.


Construction of large signaling pathways using an adaptive perturbation approach with phosphoproteomic data IN Melas , A Mitsos , DE Messinis , TS Weiss , J Saez-Rodriguez and LG Alexopoulos 2012 Mol. BioSyst., DOI: 10.1039/C2MB05482E

Large-scale network models of IL-1 and IL-6 signalling and their hepatocellular specification A Ryll, R Samaga, F Schaper, LG Alexopoulos and S Klamt, 2011 Mol. BioSyst., DOI: 10.1039/C1MB05261F

Verification of systems biology research in the age of collaborative competition. P Meyer, LG Alexopoulos, C Cho, A Fuente, D Graaf, AJ Hartemink, J Hoeng, NV Ivanov, H Koepp, R Linding, D Marbach, R Norel1, MC Peitsch, JJ Rice, A Royyuru, F Schacherer, J Sprengel1, D Vitkup, G Stolovitzky, Sept 2011 Nat Biotech 29: 9

Comparing Signaling Networks between Normal and Transformed Hepatocytes Using Discrete Logical Models. J Saez-Rodriguez*, LG Alexopoulos*, M Zhang, MK Morris,DA Lauffenburger, PK Sorger (*Equal contributors) 2011 Cancer Res 15;71(16):5400-11

Crowdsourcing Network Inference: The DREAM Predictive Signaling Network Challenge. RJ Prill, J Saez-Rodriguez, LG Alexopoulos, PK Sorger, G Stolovitzky. Sept 2011 Science Signal. Accepted

Combined logical and data-driven models for linking signalling pathways to cellular response. IN Melas, A Mitsos, DE Messinis , TS Weiss, LG Alexopoulos. Jul 2011 BMC Syst Biol. 5;5:107 [‘Highly accessed’ paper]

Setting the Standards for Signal Transduction Research. J Saez-Rodriguez*, LG Alexopoulos*, and G Stolovitzky (*Equal contributors) 2011 Sci. Signal., Vol. 4, Issue 160, p. pe10. doi: 10.1126/scisignal.20018441.

Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation. BD Cosgrove*, LG Alexopoulos*, Ta-chun Hang, BS Hendriks, PK Sorger, LG Griffith, DA Lauffenburger. (*Equal contributors) 2010 Molecular BioSystems doi: 10.1039/b926287c

Networks inferred from biochemical data reveal profound differences in TLR and inflammatory signaling between normal and transformed hepatocytes. LG Alexopoulos*, J Saez-Rodriguez*, BD Cosgrove, DA Lauffenburger, PK Sorger . (*Equal contributors) 2010 Molecular & Cellular Proteomics doi: 10.1074/mcp.M110.000406

Towards a Rigorous Assessment of Systems Biology Models: The DREAM3 Challenges. RJ Prill, D Marbach, J Saez-Rodriguez, PK Sorger, LG Alexopoulos, X Xue, ND Clarke, G Altan-Bonnet, G Stolovitzky. 2010 PLoS ONE 5(2): e9202. doi:10.1371/journal.pone.0009202

Identifying Drug Effects via Pathway Alterations using an Integer Linear Programming Optimization Formulation on Phosphoproteomic Data. A Mitsos, I Melas, P Siminelakis, A Chairakaki, J Saez-Rodriguez, and LG Alexopoulos. 2009 PloS Comp Biol. 5(12): e1000591. doi:10.1371/journal.pcbi.1000591 *BIO-IT Best Practice Award*

Discrete logic modeling to link pathway maps and functional analysis of mammalian signal transduction J Saez-Rodriguez*, LG Alexopoulos*, J Epperlein, R Samaga, DA Lauffenburger, S Klamt, PK. Sorger. (*Equal contributors). 2009. Molecular Systems Biology 5;331.  doi:10.1038/msb.2009.87

The logic of EGFR/ErbB signaling: theoretical properties and analysis of high-throughput data. Samaga R, Saez-Rodriguez J, Alexopoulos LG, Sorger PK, Klamt S. 2009. PLoS Comput Biol. 5(8):e1000438.

Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity. Cosgrove BD, King BM, Hasan MA, Alexopoulos LG, Farazi PA, Hendriks BS, Griffith LG, Sorger PK, Tidor B, Xu JJ, Lauffenburger DA. 2009 Toxicol Appl Pharmacol. 237(3):317-30

Developmental and osteoarthritic changes in Col6a1-knockout mice: Biomechanics of type VI collagen in the cartilage pericellular matrix. Alexopoulos LG, Youn I, Bonaldo P, Guilak F. Arthritis Rheum. 2009 Mar;60(3):771-9.

Flexible informatics for linking experimental data to mathematical models via DataRail. Saez-Rodriguez J, Goldsipe A, Muhlich J, Alexopoulos LG, Millard B, Lauffenburger DA, Sorger PK. Bioinformatics. 2008 Mar 15;24(6):840-7. Epub 2008 Jan 24.

The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage. Guilak F, Alexopoulos LG, Upton ML, Youn I, Choi JB, Cao L, Setton LA, Haider MA. Ann N Y Acad Sci. 2006 Apr;1068:498-512. Review.

The biomechanical role of the chondrocyte pericellular matrix in articular cartilage. Alexopoulos LG, Setton LA, Guilak F. Acta Biomater. 2005 May;1(3):317-25. Epub 2005 Mar 4.

IL-1beta decreases the elastic modulus of human tenocytes. Qi J, Fox AM, Alexopoulos LG, Chi L, Bynum D, Guilak F, Banes AJ. J Appl Physiol. 2006 Jul;101(1):189-95. Epub 2006 Apr 20.

Determination of the Poisson's ratio of the cell: recovery properties of chondrocytes after release from complete micropipette aspiration. Trickey WR, Baaijens FP, Laursen TA, Alexopoulos LG, Guilak F. J Biomech. 2006;39(1):78-87. Epub 2005 Jan 13.

Zonal uniformity in mechanical properties of the chondrocyte pericellular matrix: micropipette aspiration of canine chondrons isolated by cartilage homogenization. Guilak F, Alexopoulos LG, Haider MA, Ting-Beall HP, Setton LA. Ann Biomed Eng. 2005 Oct;33(10):1312-8.

Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage. Alexopoulos LG, Williams GM, Upton ML, Setton LA, Guilak F. J Biomech. 2005 Mar;38(3):509-17.

Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis. Alexopoulos LG, Haider MA, Vail TP, Guilak F. J Biomech Eng. 2003 Jun;125(3):323-33. *Richard Skalak Best Paper Award, ASME*

A method for quantifying cell size from differential interference contrast images: validation and application to osmotically stressed chondrocytes. Alexopoulos LG, Erickson GR, Guilak F. J Microsc. 2002 Feb;205(Pt 2):125-35.

Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways. Erickson GR, Alexopoulos LG, Guilak F. J Biomech. 2001 Dec;34(12):1527-35.

Automated standardized pupillometry with optical method for purposes of clinical practice and research. Fotiou F, Fountoulakis KN, Goulas A, Alexopoulos L, Palikaras A. Clin Physiol. 2000 Sep;20(5):336-47.



Προσφέρονται διπλωματικές σε βιοϊατρική τεχνολογία (εμβιομηχανική, ανάλυση σήματος κτλ.). Απαιτούνται καλοί βαθμοί, βασικές γνώσεις προγραμματισμού και καλή γνώση αγγλικών. Η έρευνα περιλαμβάνει συνεργασία με γνωστές εταιρίες και ερευνητικά κέντρα του εξωτερικού. Αποστείλετε e-mail στο leo[papaki]mail.ntua.gr ή περάστε από το γραφείο 301 στον κτ. Ε

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